Table 2

Summary of the significant findings from the mixed-effects regression
Trait a
 Factor b
 Coefficient estimate
 95% CI
 P-value
BW
 Sex
 -5.13
 [-6.72, -3.54]
 <0.0001

Genotype
 -2.40
 [-4.3, -0.49]
 <0.0001

Time
 -
 -
 <0.0001

     4 months
 6.34
 [4.86, 7.82]
 <0.0001

     8 months
 8.28
 [6.9, 9.66]
 <0.0001

     12 months
 11.73
 [10.33, 13.13]
 <0.0001

Genotype*Time
 -
 -
 0.0003

     Genotype*4 months
 -1.52
 [-3.55, 0.52]
 0.1415

     Genotype*8 months
 -2.60
 [-4.56, -0.64]
 0.0102

     Genotype*12 months
 -4.79
 [-6.88, -2.69]
 <0.0001
LVM
 BW
 0.88
 [-0.06, 1.81]
 <0.0001

Sex
 -4.50
 [-13.36, 4.35]
 0.2636

Genotype
 -8.85
 [-16.91, -0.78]
 0.7443

Time
 -
 -
 0.0003

     4 months
 15.35
 [7.9, 22.8]
 0.0001

     8 months
 18.55
 [10.27, 26.84]
 <0.0001

     12 months
 19.29
 [8.84, 29.74]
 0.0005
EF
 Sex
 1.06
 [-2.55, 4.66]
 0.4924

Genotype
 3.46
 [-0.02, 6.94]
 0.0334

Time
 -
 -
 0.0027

     4 months
 -1.43
 [-5.58, 2.72]
 0.4947

     8 months
 -5.42
 [-9.44, -1.4]
 0.009

     12 months
 -7.30
 [-11.55, -3.06]
 0.001
Heart rate
 Sex
 -48.49
 [-74.64, -22.33]
 0.1958

Genotype
 -42.08
 [-67.96, -16.2]
 0.698

Time
 -
 -
 0.0519

     4 months
 4.99
 [-17.61, 27.58]
 0.6611

     8 months
 -23.16
 [-44.79, -1.54]
 0.0362

     12 months
 -20.67
 [-43.49, 2.15]
 0.0751

Sex*Genotype
 73.26
 [35.93, 110.6]
 0.0004
dV/dtmax.EDV-1
 Sex
 0.002
 [0.001, 0.004]
 0.0048

Genotype
 0.000
 [-0.001, 0.002]
 0.8454

Time

0.0009

     4 months
 -0.001
 [-0.003, 0.001]
 0.2688

     8 months
 -0.003
 [-0.005, -0.001]
 0.0017

     12 months
 -0.004
 [-0.005, -0.002]
 0.0004

a Traits for which at least one factor in the model had significant (P < 0.01) effects.

b Estimated effects of KO compared to WT (baseline) for Genotype, female compared to male (baseline) for Sex, and trait values at 4 months, 8 months, and 12 months compared to trait values at 6 weeks (baseline) for Time (3df test)

Schneider et al. Journal of Cardiovascular Magnetic Resonance 2008 10:9   doi:10.1186/1532-429X-10-9