This article is part of the supplement: Abstracts of the 16th Annual SCMR Scientific Sessions

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Assessment of coronary artery disease using 3.0T magnetic resonance coronary angiography: a national multicenter trial

Qi Yang1*, Kuncheng Li1, Bin Sun2, Hong Yun3, Lijun Tang4, Shurong Li6, Zhenbin Cao8, Junling Xu5, Mengqi Wei7 and Lixin Jin9

  • * Corresponding author: Qi Yang

Author Affiliations

1 Radiology Department, Xuanwu Hospital, Capital Medical University, Beijing, China

2 Radiology Department, Fujian Union Hospital, Fujian Medical University, Fuzhou, China

3 Radiology Department, Zhongshan hospital, Fudan University, Shanghai, China

4 Radiology Department, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, China

5 Radiology Department, Henan Provincial Hospital, Zhengzhou, China

6 Radiology Department, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

7 Radiology Department, Xijing Hospital, Fourth Military Medical University, Xian, China

8 Radiology Department, Wuhan Union Hospital, Huazhong University of Science, Wuhan, China

9 Siemens Healthcare, MR Collaboration NE Asia, Shanghai, China

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Journal of Cardiovascular Magnetic Resonance 2013, 15(Suppl 1):E5 doi:10.1186/1532-429X-15-S1-E5


The electronic version of this article is the complete one and can be found online at: http://www.jcmr-online.com/content/15/S1/E5


Published:30 January 2013

© 2013 Yang et al; licensee BioMed Central Ltd.

Background

3.0T contrast enhanced whole-heart coronary magnetic resonance angiography (MRA) is a promising method for noninvasive, radiation-free detection and exclusion of obstructive coronary artery disease (CAD); however, the accuracy of this approach has not been determined in a multicenter trial.

Methods

An ECG-triggered, navigator-gated, inversion-recovery prepared, segmented gradient-echo sequence was used for image acquisition in 272 patients with suspected CAD at 8 hospitals. The accuracy of coronary MRA for detecting a 50% diameter reduction was determined using X-ray coronary angiography as the reference method. Using an intention-to-diagnose approach, all coronary arteries were included for the evaluation regardless of the image quality of coronary MRA to avoid overestimation of the diagnostic accuracy. Clinical Trial Registration—URL: http://clinicaltrials.gov webcite. Unique identifier: NCT01024478.

Results

Acquisition of coronary MRA was successfully completed in 235 of 272 (86%) patients with average imaging time of 9.5±1.6 minutes. The areas under the receiver-operator characteristic curve from MRA images according to vessel- and patient-based analyses were 0.90 (95% confidence interval [CI]: 0.88 to 0.95) and 0.88 (95% CI: 0.83 to 0.93), respectively. The sensitivity and specificity of MRA on per-patient basis were 91% and 80%, respectively.

thumbnailFigure 1. Curved planar reconstruction (CPR) image (A), Sliding thin slab maximum intensity projection (MIP) image (B), MIP image of coronary tree (C), and volume-rendered image (D) detect coronary artery stenoses in the LAD (arrow) and first diagonal branch (arrowhead). Good agreement is observed between coronary MRA and X-ray coronary angiography.

Conclusions

Among patients who were scheduled to obtain conventional x-ray coronary angiography, we found that coronary MRA at 3.0T demonstrates high accuracy for detection of significant coronary artery stenosis. It warrants greater consideration as a suitable noninvasive method to exclude obstructive CAD.

Funding

National Basic Research Program 973 (grant no. 2010CB732600) from Ministry of Science and Technology, China; National Natural Science Foundation of China, grant number 30900355; National Institute of Health, grants numbers NIBIB EB002623 and NHLBI HL38698.